Skin Irritation Testing in Rabbits Complicated by Dermal Mucormycosis

Evaluation of dermal irritation and skin sensitization due to vitacoxib

The prediction of side-effects is a key issue in the REACH initiative on chemicals in the preclinical testing of drugs. The dermal irritation and skin sensitization toxicity potential of a new molecule, vitacoxib, were invested in rabbits and guinea pigs in compliance with the Organization for Economic Cooperation and Development guideline. To assess dermal irritation, rabbits were dermally att...

Alternative methods for skin irritation testing: the current status.

The potential for chemicals to cause skin corrosion or skin irritation is an important consideration in establishing procedures for the safe handling, packing and transport of chemicals. The determination of skin corrosion and irritation potential is therefore included in international regulatory requirements for the testing of chemicals. The standard approach used involves applying the test ma...

Skin irritation and corrosion.

A Dermal Piercing Complicated by Mycobacterium fortuitum

Background. Dermal piercings have recently become a fashion symbol. Common complications include hypertrophic scarring, rejection, local infection, contact allergy, and traumatic tearing. We report a rare case of Mycobacterium fortuitum following a dermal piercing and discuss its medical implications and treatments. Case. A previously healthy 19-year-old woman presented complaining of erythema ...

Performance Standards for Applying Human Skin Models to in Vitro Skin Irritation Testing Content

3 INTRODUCTION......................................................................................................................................... 2 3.1 REGULATORY RATIONALE FOR USING IN VITRO TEST METHODS TO ASSESS SKIN IRRITATION ................... 3 3.2 PRINCIPLE OF IN VITRO HUMAN SKIN MODEL SYSTEMS FOR SKIN IRRITATION TESTING............................. 3 4 GENERAL SKIN MODEL PERFORM...